Mediterr J Rheumatol 2016;27(3):111-4
Bilateral pitting oedema in an elderly patient: a typical case of RS3PE syndrome and literature review
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Private Practice Rheumatologist, Patras, Greece


Remitting Seronegative Symmetrical Synovitis with Pitting (o)Edema (RS3PE) syndrome is a rare inflammatory syndrome affecting the elderly, characterized by diffuse symmetrical swelling of the extremities and rapid response to steroids. We present a case of an 84-year old lady, who presented with the typical clinical, laboratory and ultrasonographic findings of the disease, and responded promptly to medium-dose steroids. Then, the epidemiology, pathogenesis, clinical features, differential diagnosis and possible associations of the syndrome with other rheumatological conditions and malignancies are briefly discussed.