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Mediterr J Rheumatol 2023;34(3):398-402
Prevalence and Clinical Implications of Scleroderma-Specific Autoantibodies in Seronegative Patients with Sicca Complaints
Authors Information

1Department of Physiology, Medical School of Athens, National and Kapodistrian University of Athens, Athens, Greece
2Department of Pathophysiology, Medical School of Athens, National and Kapodistrian University of Athens, Athens, Greece

N Marketos, CP Mavragani

Abstract

Introduction: Previous studies have revealed the presence of anticentromere antibodies in patients with Sjögren's syndrome (SS), predominantly in those serologically negative for antibodies against Ro/SSA and La/SSB antigens (seronegative). The prevalence and clinical significance of specific autoantibodies for Systemic Sclerosis (SSc) in seronegative patients with sicca complaints (dry eyes, dry mouth) have not yet been studied. Aim of the study: Investigate the prevalence and clinical significance of SSc-specific autoantibodies in seronegative patients with sicca complaints. Methods: Among 212 patients with sicca symptoms that were investigated at the Laboratory of Physiology, Medical School of Athens, National and Kapodistrian University of Athens between the years 2017-2020 for the presence of antibodies against Ro/SSA and La/SSB antigens,  we found 106 patients that did not meet the criteria for SS following a thorough investigation. We have already performed serological tests of 13 specific autoantibodies for Scleroderma by using the test EUROLINE Systemic Sclerosis (Nucleoli) profile (IgG) (EUROIMMUNΕ Medizinische Labordiagnostika AG) in 51 of these patients. Additionally, their demographic, clinical, and laboratory data have been recorded. Results: The presence of the specific Scleroderma autoantibodies was noticed in 29/51 patients (57%). More precisely, in 7/29 patients (24%) we recorded NOR90 as well as Th/To, in 5/29 (17%) Ku & Ro52, in 4/29 (14%) CENP-B, in 3/29 (10%) CENP-A & RP155, in 2/29 (7%) RP11 & PM/Scl 75 and finally in 1/29 (3.5%) Scl70, PM/Scl 100 & Fibrillarin respectively. The subsequent follow-up of these patients revealed signs of pulmonary hypertension and interstitial lung disease in some cases. Conclusions: The high prevalence of SSc-specific autoantibodies in seronegative sicca patients discloses those needing tighter follow-up and systematic treatment.


Cite this article as: Marketos N, Mavragani CP. Prevalence and Clinical Implications of Scleroderma-Specific Autoantibodies in Seronegative Patients with Sicca Complaints. Mediterr J Rheumatol 2023;34(3):398-402.

Article Submitted: 11 July 2021; Revised Form: 11 Dec 2022; Article Accepted: 12 Dec 2022; Available Online: 8 Aug 2023

https://doi.org/10.31138/mjr.20230808.pa

This work is licensed under a Creative Commons Attribution 4.0 International License.

©2023 The Author(s).