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Mediterr J Rheumatol 2023;34(2):245-51
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Case Series on DRESS: An Unpredictable Adverse Drug Reaction
Maryam Fatima1, Salwa Sahar Azimi2, Soumya Ashwini1, Madhuri H Radhakrishna1
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1AIG Hospitals, India
2G. Pulla Reddy College of Pharmacy, India

Abstract
Drug rash with eosinophilia and systemic symptoms syndrome (DRESS) is a potentially life-threatening, drug-induced, multi-organ system reaction. The most frequently involved organ is the liver, followed by the kidneys and lungs. Early detection and diagnosis followed by withdrawal of the offending agent is vital to minimise the associated morbidity and mortality, and a detailed drug history is vital to identify the causative drugs. Although Spanish guidelines were developed by a panel of allergy specialists from the Drug Allergy Committee of the Spanish Society of Allergy and Clinical Immunology (SEAIC) and are available in literature from 2020, many clinicians are still unaware about the management of this syndrome. Framing National guidelines for the early diagnosis and pharmaco-therapeutic management of DRESS will help healthcare professionals to save the patients from unintended vulnerability. We hereby present a case series on DRESS.

Cite this article as: Fatima M, Azimi SS, Ashwini S, Radhakrishna MH. Case Series on DRESS: An Unpredictable Adverse Drug Reaction. Mediterr J Rheumatol 2023;34(2):245-51.

Article Submitted: 23 Aug 2022; Article Accepted: 15 Sep 2022; Available Online: 30 Jun 2023

https://doi.org/10.31138/mjr.34.2.245

This work is licensed under a Creative Commons Attribution 4.0 International License.

©2023 The Author(s).

Keywords: maculopapular rash, lymphadenopathy, vulnerability, offending drug, corticosteroids