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Mediterr J Rheumatol 2023;34(2):252-6
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Pulmonary-Renal Syndrome During COVID-19 Pandemic Revealed a Rare Case of Anti-GBM Disease
Aglaia Chalkia1, Christos Koutsianas2, Emelina Stampolliou1, Panagiota Giannou1, Harikleia Gakiopoulou3, Dimitrios Vassilopoulos2, Dimitrios Petras1
Authors Information

1Nephrology Department, Hippokration General Hospital, Athens, Greece

22nd Department of Medicine and Laboratory, Clinical Immunology - Rheumatology Unit, National and Kapodistrian University of Athens School of Medicine, Hippokration General Hospital, Athens, Greece

³1st Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

Abstract

Anti-GBM disease is a rare, life-threatening small vessel vasculitis caused by circulating anti-GBM antibodies resulting to rapidly progressive glomerulonephritis and/or pulmonary haemorrhage. The gold standard for the diagnosis is the renal biopsy with the pathognomonic finding of linear deposition of IgG along the glomerular capillaries. Early diagnosis and intervention are key determinants of the response to therapy and long-term prognosis of these patients. However, during COVID-19 pandemic recognizing a pulmonary-renal syndrome caused by autoimmune diseases has become challenging. Herein, we aimed to describe a rare case of anti-GBM disease with pulmonary haemorrhage and rapidly progressive glomerulonephritis in a young man in a tertiary referral hospital in Greece, while COVID-19 pandemic was at its peak.  Although the patient presented high level of creatinine and crescents, the early diagnosis and start of treatment resulted to favourable renal prognosis.


Cite this article as: Chalkia A, Koutsianas C, Stampolliou E, Giannou P, Gakiopoulou H, Vassilopoulos D, Petras D. Pulmonary-Renal Syndrome During COVID-19 Pandemic Revealed a Rare Case of Anti-GBM Disease. Mediterr J Rheumatol 2023;34(2):252-6,

Article Submitted: 15 Jan 2023; Revised Form: 16 Feb 2023; Article Accepted: 21 Feb 2023; Available Online: 30 Jun 2023

https://doi.org/10.31138/mjr.34.2,252

This work is licensed under a Creative Commons Attribution 4.0 International License.

©2023 The Author(s).

Keywords: anti-GBM disease, rapidly progressive glomerulonephritis, pulmonary haemorrhage