Volume 35, Issue 1, March 2024

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Mediterr J Rheumatol 2024;35(1):184-6
Penicillamine-Induced Localised Cutis Laxa in a Patient with Wilson Disease: A Case Report
Authors Information

12nd Department of Dermatology-Venereology, National Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece

2Private Dermatology Practice, Dermatology Study Group, Lamia, Greece

E Routsi, A Kanelleas, G Pappa, A Katoulis


Introduction: Wilson disease is a rare genetic disorder, characterised by excessive deposition of copper in the liver, brain, and other tissues. Penicillamine, a copper-chelating agent, is used in high doses in the treatment of Wilson disease leading to a variety of cutaneous reactions, including hypersensitivity reactions, pseudoxanthoma elasticum, elastosis perforans serpiginosa, anetoderma, and cutis laxa (CL). We present a rare case of localised CL induced by penicillamine for Wilson disease, in the absence of elastosis perforans serpiginosa. Case Description: A 41-year-old male with Wilson disease treated with long-term high-dose penicillamine was referred to us for a basal cell carcinoma on the scalp. On physical examination, diffusely flaccid and redundant skin on the right side of the neck were observed. Histopathology revealed findings consistent with CL. Conclusion: Long-term treatment with penicillamine for Wilson disease may induce localized CL, possibly by direct inhibition of cross-linkage of collagen fibres.

Cite this article as: Routsi E, Kanelleas A, Papaefthymiou V, Pappa G, Katoulis A. Penicillamine-Induced Localised Cutis Laxa in a Patient with Wilson Disease: A Case Report. Mediterr J Rheumatol 2024;35(1):184-6.

Article Submitted: 28 Feb 2023; Revised Form: 11 Apr 2023; Article Accepted: 15 May 2023; Available Online: 23 Aug 2023

This work is licensed under a Creative Commons Attribution 4.0 International License.

©2024 The Author(s).