Mediterr J Rheumatol 2019;30(1):3-6
From Rheumatology 1.0 to Rheumatology 4.0 and beyond: the contributions of Big Data to the field of rheumatology
Authors Information

1Postgraduate School of Public Health, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy

2Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy

3Young Dermatologists Italian Network (YDIN), GISED, Bergamo, Italy

4Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA

5Department of Health Sciences, Section of Medical History and Ethics, University of Genoa, Italy

6UNESCO CHAIR Anthropology of Health - Biosphere and Healing System, University of Genoa, Italy

  1. Mansour R, Azrielant S, Watad A, Tiosano S, Yavne Y, Comanesther D, et al. Venous thromboembolism events among RA patients. Mediterr J Rheumatol 2019;30(1):13-18.
  2. Ungprasert P, Srivali N, Spanuchart I, Thongprayoon C, Knight EL. Risk of venous thromboembolism in patients with rheumatoid arthritis: a systematic review and meta-analysis. Clin Rheumatol 2014 Mar;33(3):297-304. [https://doi.org/10.1007/s10067-014-2492-7] [PMID: 24424839]
  3. Misra DP, Agarwal V. Real-world evidence in rheumatic diseases: relevance and lessons learnt. Rheumatol Int 2019 Mar;39(3):403-416. [https://doi.org/10.1007/s00296-019-04248-1] [PMID: 30725156]
  4. Miksad RA, Abernethy AP. Harnessing the Power of Real-World Evidence (RWE): A Checklist to Ensure Regulatory-Grade Data Quality. Clin Pharmacol Ther 2018 Feb;103(2):202-5. [https://doi.org/10.1002/cpt.946] [PMID: 29214638] [PMCID: PMC5814721]
  5. Cho SK, Sung YK. A paradigm shift in studies based on rheumatoid arthritis clinical registries. Korean J Intern Med 2019 Feb 18. [https://doi.org/10.3904/kjim.2018.440] [PMID: 30759964]
  6. Brito-Zerón P, Acar-Denizli N, Ng WF, Zeher M, Rasmussen A, Mandl T, et al. How immunological profile drives clinical phenotype of primary Sjögren's syndrome at diagnosis: analysis of 10,500 patients (Sjögren Big Data Project). Clin Exp Rheumatol 2018 May-Jun;36 Suppl 112(3):102-12. [PMID: 30156539]
  7. Schmajuk G, Yazdany J. Leveraging the electronic health record to improve quality and safety in rheumatology. Rheumatol Int 2017 Oct;37(10):1603-10. [https://doi.org/10.1007/s00296-017-3804-4] [PMID: 28852846] [PMCID: PMC5693630]
  8. Cook JA, Collins GS. The rise of big clinical databases. Br J Surg 2015 Jan;102(2):e93-e101. [https://doi.org/10.1002/bjs.9723] [PMID: 25627139]
  9. Deshpande S. History of rheumatology. Med J DY Patil Univ 2014;7:119-23.
  10. Entezami P, Fox DA, Clapham PJ, Chung KC. Historical perspective on the etiology of rheumatoid arthritis. Hand Clin 2011 Feb;27(1):1-10. [https://doi.org/10.1016/j.hcl.2010.09.006] [PMID: 21176794] [PMCID: PMC3119866]
  11. Sakkas LI, Tronzas P. The Greek (Hellenic) rheumatology over the years: from ancient to modern times. Rheumatol Int 2019, in press. [https://doi.org/10.1007/s00296-019-04261-4]
  12. Joshi VR, Poojary VB. William Heberden (elder) (1710-1801). J Assoc Physicians India 2013 Dec;61(12):946-7. [PMID: 24968564]
  13. Baruch JZ. [Guillaume de Baillou, precursor of modern rheumatology. Some biographical data with contemplations]. Ned Tijdschr Geneeskd 1965 Oct 30;109(44):2086-91. [PMID: 5321429]
  14. Stochik AM, Zatravkin SN. [The contribution of T. Sydenham (1624-1689) to the formation of modern Western medicine (on the occasion of the 390th anniversary of his birth)]. Ter Arkh 2014;86(8):138-42. [PMID: 25306762]
  15. Landré-Beauvais AJ. The first description of rheumatoid arthritis. Unabridged text of the doctoral dissertation presented in 1800. Joint Bone Spine 2001 Mar;68(2):130-43. [PMID: 11324929]
  16. Spender JK. On some Hitherto Undescribed Symptoms in the Early History of Osteoarthritis. The So-Called Rheumatoid Arthritis. Br Med J 1888 Apr 14;1(1424):781-3. [PMID: 20752255] [PMCID: PMC2197518]
  17. Dobson GP, Letson HL, Grant A, McEwen P, Hazratwala K, Wilkinson M, et al. Defining the osteoarthritis patient: back to the future. Osteoarthritis Cartilage 2018 Aug;26(8):1003-7. [https://doi.org/10.1016/j.joca.2018.04.018] [PMID: 29775734]
  18. Dundas D. An account of a peculiar Disease of the Heart. Med Chir Trans 1809;1:37-46. [PMID: 20895121] [PMCID: PMC2128801]
  19. Dochez AR. Homer Fordyce Swift, 1881-1953. Trans Assoc Am Physicians 1954;67:25-7. [PMID: 13216807]
  20. Lawy HS. Use and interpretation of the antistreptolysin test. Ann Rheum Dis. 1960;19:42-7. [PMID: 14414765] [PMCID: PMC1007358]
  21. Wu IB, Schwartz RA. Reiter's syndrome: the classic triad and more. J Am Acad Dermatol 2008 Jul;59(1):113-21. [https://doi.org/10.1016/j.jaad.2008.02.047] [PMID: 18436339]
  22. Pasero G, Marson P. [Wars in the history of rheumatology]. Reumatismo 2007 Oct-Dec;59(4):332-7. [PMID: 18157291]
  23. Benedek TG. History of Rheumatic Diseases. In: (J.H. Klippel, Ed.) “Primer on the Rheumatic diseases”. Atlanta, Arthritis Foundation, 1997;11:1–5.
  24. Burmester GR. Rheumatology 4.0: big data, wearables and diagnosis by computer. Ann Rheum Dis 2018 Jul;77(7):963-5. [https://doi.org/10.1136/annrheumdis-2017-212888] [PMID: 29802224] [PMCID: PMC6029631]
  25. Burmester GR, Häupl T. Big data-also relevant in rheumatology? Z Rheumatol. 2018 Apr;77(3):192-194.
  26. Sfikakis PP, Bournia VK, Sidiropoulos P, Boumpas DT, Drosos AA, Kitas GD, et al. Biologic treatment for rheumatic disease: real-world big data analysis from the Greek country-wide prescription database. Clin Exp Rheumatol 2017 Jul-Aug;35(4):579-85. [PMID: 28281458]
  27. Brito-Zerón P, Acar-Denizli N, Zeher M, Rasmussen A, Seror R, Theander E, et al. Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjögren Project Consortium. Ann Rheum Dis 2017 Jun;76(6):1042-50. [https://doi.org/10.1136/annrheumdis-2016-209952] [PMID: 27899373]
  28. Symmons DP. Epidemiology research in rheumatology-progress and pitfalls. Nat Rev Rheumatol 2015 Nov;11(11):631-8. [https://doi.org/10.1038/nrrheum.2015.92] [PMID: 26150125]
  29. Gonzalez A, Valdes AM. Big data boost for osteoarthritis genetics. Nat Rev Rheumatol 2018 Jul;14(7):387-88. [https://doi.org/10.1038/s41584-018-0023-7] [PMID: 29899548]
  30. Landewé RBM, van der Heijde D. "Big Data" in Rheumatology: Intelligent Data Modeling Improves the Quality of Imaging Data. Rheum Dis Clin North Am 2018 May;44(2):307-15. [https://doi.org/10.1016/j.rdc.2018.01.007] [PMID: 29622297]
  31. Winter DR. Thinking BIG rheumatology: how to make functional genomics data work for you. Arthritis Res Ther 2018 Feb 12;20(1):29. [https://doi.org/10.1186/s13075-017-1504-9] [PMID: 29433549] [PMCID: PMC5810031]
  32. Ramos-Casals M, Brito-Zerón P, Kostov B, Sisó-Almirall A, Bosch X, Buss D, et al. Google-driven search for big data in autoimmune geoepidemiology: analysis of 394,827 patients with systemic autoimmune diseases. Autoimmun Rev 2015 Aug;14(8):670-9. [https://doi.org/10.1016/j.autrev.2015.03.008] [PMID: 25842074]
  33. Bragazzi NL, Watad A, Brigo F, Adawi M, Amital H, Shoenfeld Y. Public health awareness of autoimmune diseases after the death of a celebrity. Clin Rheumatol 2017 Aug;36(8):1911-7. [https://doi.org/10.1007/s10067-016-3513-5] [PMID: 28000011]