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Volume 35, Issue 1, March 2024



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Mediterr J Rheumatol 2020;31(4):433-5
Article Links
Hydroxychloroquine and QT Prolongation in Older Patients with Rheumatic Diseases: Who is afraid of the Boogeyman? We are not!
Alberto Castagna1, Giovanni Ruotolo2, Ciro Manzo3
Authors Information

1. Azienda Sanitaria Provinciale Catanzaro, Geriatric Medicine department - Fragility Outpatient Clinic, Casa della Salute Chiaravalle Centrale, Catanzaro, Italy

2. Azienda Ospedaliera Pugliese-Ciaccio di Catanzaro, Geriatric Unit, General Hospital, Catanzaro, Italy

3. Azienda Sanitaria Locale Napoli 3 sud, Internal and Geriatric Medicine department – Geronthorheumatological Outpatient Clinic, poliambulatorio “Mariano Lauro”, Sant’Agnello, Naples, Italy

Alberto Castagna, Ciro Manzo 

References
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  2. Coronavirus Disease (COVID-19) events as they happen. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-as-theyhappen. Accessed July 4, 2020.
  3. Bogdanos DP, Daniil Z, Zakynthinos E, Gourgoulianis K, Sakkas LI. When there is a pandemic there is no time to waste: should we have hydroxychloroquine in our armoury against COVID-19 infected patients? Mediterr J Rheumatol 2020;31:94-7.
  4.  Chorin E, Dai M, Shulman E, Wadhwani L, Bar-Cohen R, Barbhaiya C, et al. The QT interval in patients with COVID-19 treated with hydroxychloroquine and azithromycin. Nat Med 2020 Jun;26(6):808-09.
  5. Mercuro NJ, Yen CF, Shim DJ, Maher TR, McCoy CM, Zimetbaum PJ, et al. Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19). JAMA Cardiol 2020 Sep 1;5(9):1036-41.  
  6. Passman R, Kadish A. Polymorphic ventricular tachycardia, long Q-T syndrome, and torsades de pointes. Medical Clinics of North America. 2001;85:321–341. doi: 10.1016/s0025-7125(05)70318-7.
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  10. Michishita R, Fukae C, Mihara R, Ikenaga M, Morimura K, Takeda N, et al. Association between the physical activity and heart rate corrected-QT interval in older adults. Geriatr Gerontol Int 2015;15:895-901.
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