Volume 26, Issue 1, April 2015
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1479250602
Mediterr J Rheumatol 2015; 26(1): 64-67
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Regulatory B cells open new therapeutic strategies for autoimmune diseases
Abstract
Regulatory B cells (Bregs) play a significant role in suppressing proinflammatory immune responses and preventing autoimmunity. In human systemic lupus erythematosus and ANCA vascuitis, Bregs may be defective. Ex vivo expansion of Bregs and readministration to experimental animals suppressed experimental autoimmune diseases. This opens the way for new therapeutic strategies in human autoimmune diseases. Keywords: Systemic sclerosis, treatment, methotrexate, bosentan, digital ulcer, scleroderma renal crisis
