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Mediterr J Rheumatol 2018;29(1):59-61
The effect of Apremilast on signal transduction and IL-10 production in CD39high regulatory B cells in patients with psoriatic arthritis
Authors Information

1: Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece

2: Department of Dermatology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece

References
  1. Mauri C, Menon M. Human regulatory B cells in health and disease: therapeutic potential. J Clin Invest 2017;127:772-9.
  2. Kalampokis I, Yoshizaki A, Tedder TF. IL-10-producing regulatory B cells (B10 cells) in autoimmune disease. Arthritis Res Ther 2013;15 Suppl 1:S1. doi: 10.1186/ar3907.
  3. Mavropoulos A, Simopoulou T, Varna A, Liaskos C, Katsiari CG, Bogdanos DP, Sakkas LI. Breg Cells Are Numerically Decreased and Functionally Impaired in Patients With Systemic Sclerosis. Arthritis Rheumatol 2016;68:494-504.
  4. Sakkas L I, Bogdanos D P. Are psoriasis and psoriatic arthritis the same disease? The IL-23/IL-17 axis data. Autoimmun Rev 2017;16:10-5. doi: 10.1016/j.autrev.2016.09.015.
  5. Mavropoulos A, Varna A, Zafiriou E, Liaskos C, Alexiou I, Roussaki-Schulze A, et al. IL-10 producing Bregs are impaired in psoriatic arthritis and psoriasis and inversely correlate with IL-17- and IFNγ-producing T cells. Clin Immunol 2017;184:33-41.
  6. Lampropoulou V, Calderon-Gomez E, Roch T, Neves P, Shen P, Stervbo U, et al. Suppressive functions of activated B cells in autoimmune diseases reveal the dual roles of Toll-like receptors in immunity. Immunol Rev 2010;233:146-61.
  7. Carter N A, Rosser E C, Mauri C. Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis. Arthritis Res Ther.2012 8;14:R32.
  8. Flores-Borja F, Bosma A, Ng D, Reddy V, Ehrenstein M R, Isenberg D A, Mauri C. CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation. Sci Transl Med 2013;5:173ra23.
  9. Kessel A, Haj T, Peri R, Snir A, Melamed D, Sabo E, Toubi E. Human CD19(+)CD25(high) B regulatory cells suppress proliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells. Autoimmun Rev. 2012;11:670-7.
  10. Figueiro F, Muller L, Funk S, Jackson E K, Battastini A M, Whiteside T L. Phenotypic and functional characteristics of CD39high human regulatory B cells (Breg). Oncoimmunology 2016 Feb;5(2):e1082703. 
  11. Saze Z, Schuler P J, Hong C S, Cheng D, Jackson E K, Whiteside T L. Adenosine production by human B cells and B cell-mediated suppression of activated T cells. Blood. 2013;122:9-18. 
  12. Schuler P J, Saze Z, Hong C S, Muller L, Gillespie D G, Cheng D, et al. Human CD4+ CD39+ regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+ exosomes or CD73+ cells. Clin Exp Immunol 2014;177:531-43.
  13. Bopp T, Becker C, Klein M, Klein-Hessling S, Palmetshofer A, Serfling E, et al. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J Exp Med 2007;204:1303-10. 
  14. Sakkas L I, Mavropoulos A, Bogdanos DP. Phosphodiesterase 4 Inhibitors in Immune-mediated Diseases: Mode of Action, Clinical Applications, Current and Future Perspectives. Curr Med Chem. 2017;24:3054-67.
  15. Iyer S S, Cheng G. Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Crit Rev Immunol 2012;32:23-63.
  16. Liao H, Hyman M C, Baek A E, Fukase K, Pnsky D J. cAMP/CREB-mediated transcriptional regulation of ectonucleoside triphosphate diphosphohydrolase 1 (CD39) expression. J Biol Chem 2010;285:14791-805. doi: 10.1074/jbc.M110.116905.
  17. Kochetkova I, Golden S, Holderness K, Calls G, Pascula D W. IL-35 stimulation of CD39+ regulatory T cells confers protection against collagen II-induced arthritis via the production of IL-10. J Immunol 2010;184:7144-53. doi: 10.4049/jimmunol.0902739.