Mediterr J Rheumatol 2017;28(4):212-6
Anti-synthetase syndrome presenting with interstitial lung disease
Authors Information

1: Department of Rheumatology, St. Paul’s Hospital, Thessaloniki, Greece

2: Department of Endocrinology, Asclepeion Hospital, Athens
  1. Katzap E, Barilla-LaBarca M L, Marder G. Antisynthetase syndrome. Curr Rheumatol Rep 2011;13:175-81.
  2. Noguchi E, Uruha A, Suzuki S, Hamanaka K, Ohnuki Y, Tsugawa J, et al. Skeletal muscle involvement in antisynthetase syndrome. JAMA Neurol 2017;74:992-9.
  3. Witt L J, Curran J J, Strek M E. The diagnosis and treatment of antisynthetase syndrome. Clin Pulm Med 2016;23:218-26.
  4. Lundberg I E, Miller F W, Tjärnlund A, Bottai M. Diagnosis and classification of idiopathic inflammatory myopathies. J Intern Med 2016;280:39-51.
  5. Mathews M B, Reichlin M, Hughes G R, Bernstein R M. Anti-threonyl-tRNA synthetase, a second myositis-related autoantibody. J Exp Med 1984;160:420-34.
  6. Marguerie C, Bunn C C, Beynon H L, Bernstein R M, Hughes J M, So A K, et al. Polymyositis, pulmonary fibrosis and autoantibodies to aminoacyl-tRNA synthetase enzymes. Q J Med 1990;77:1019-38.
  7. Friedman A W, Targoff I N, Arnett F C. Interstitial lung disease with autoantibodies against aminoacyl-tRNA synthetases in the absence of clinically apparent myositis. Semin Arthritis Rheum 1996;26:459-67.
  8. Connors G R, Christopher-Stine L, Oddis C V, Danoff S K. Interstitial lung disease associated with the idiopathic inflammatory myopathies: what progress has been made in the past 35 years? Chest 2010;138:1464-74.
  9. Solomon J, Swigris J J, Brown K K. Myositis-related interstitial lung disease and antisynthetase syndrome. J Bras Pneumol 2011;37:100-9.
  10. Debray M P, Borie R, Revel M P, Naccache J M, Khalil A, Toper C, et al. Interstitial lung disease in anti-synthetase syndrome: Initial and follow-up CT findings. Eur J Radiol 2015;84:516–23.
  11. Joffe M M, Love L A, Leff R L, Fraser D D, Targoff I N, Hicks J E, et al. Drug therapy of the idiopathic inflammatory myopathies: predictors of response to prednisone, azathioprine, and methotrexate and a comparison of their efficacy. Am J Med 1993;94:379-87.
  12. Uribe L, Ronderos D M, Díaz M C, Gutierrez J M, Mallarino C, Fernandez-Avila D G. Antisynthetase antibody syndrome: case report and review of the literature. Clin Rheumatol 2013;32:715-9.
  13. Hervier B, Masseau A, Mussini J M, Audrain M, Hamidou M A. Long-term efficacy of mycophenolate mofetil in a case of refractory antisynthetase syndrome. Joint Bone Spine 2009;76:575-6.
  14. Keir G J, Maher T M, Hansell D M, Denton C P, Ong V H, Singh S, et al. Severe interstitial lung disease in connective tissue disease: rituximab as rescue therapy. Eur Respir J 2012;40:641-8.
  15. Nalotto L, Iaccarino L, Zen M, Gatto M, Borella E, Domenighetti M, et al. Rituximab in refractory idiopathic inflammatory myopathies and antisynthetase syndrome: personal experience and review of the literature. Immunol Res 2013;56:362-70.