Loading...
 
Back to the list
Mediterr J Rheumatol 2021;32(3):227-36
Article Links
Prevention of Osteoarthritis Progression by Statins, Targeting Metabolic and Inflammatory Aspects: A Review
Behzad Heidari1, Mansour Babaei1,2, Behnaz Yosefghahri2
Authors Information

1. Mobility Impairment Research Centre, Babol University of Medical Sciences, Babol, Iran

2. Department of Medicine, Division of Rheumatology, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran

Keywords: osteoarthritis, statin therapy, symptom, incidence, progression
References
  1. Heidari B. Knee osteoarthritis prevalence, risk factors, pathogenesis and features: Part I. Caspian J Intern Med 2011;2(2):205-12.
  2. Heidari B. Knee osteoarthritis diagnosis, treatment and associated factors of progression: part II. Caspian J Intern Med 2011;2(3):249-55.
  3. Wang T, He C. Pro-inflammatory cytokines: The link between obesity and osteoarthritis. Cytokine Growth Factor Rev 2018;44:38-50.
  4. Hacken B, Rogers A, Chinchilli V, Silvis M, Mosher T, Black K. Improvement in knee osteoarthritis pain and function following bariatric surgery: 5-year follow-up. Surg Obes Relat Dis 2019;15(6):979-84.
  5. Issa RI, Griffin TM. Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammation. Pathobiol Aging Age Relat Dis 2012;2(2012):10.3402/pba.v2i0.17470.
  6. Urban H, Little CB. The role of fat and inflammation in the pathogenesis and management of osteoarthritis. Rheumatology 2018;57:iv10iv21.
  7. Hijssen E, van Caam A, van der Kraan PM. Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis. Rheumatology (Oxford) 2015;54(4):588-600.
  8. Hajian-Tilaki K, Heidari B, Firouzjahi AR. Clustering of cardio metabolic risk factors in Iranian adult population: A growing problem in the north of Iran. Diabetes Metab Syndr 2017;11 Suppl 1:S277-S281.
  9. Babaei M, Javadian Y, Narimani H, Ranaei M, Heidari B, Basereh H, et al. Correlation between systemic markers of inflammation and local synovitis in knee osteoarthritis. Caspian J Intern Med 2019 Fall;10(4):383-7.
  10. Findlay DM. Vascular pathology and osteoarthritis. Rheumatology (Oxford) 2007;46(12):1763-8.
  11. Gkretsi V, Simopoulou T, Tsezou A. Lipid metabolism and osteoarthritis: lessons from atherosclerosis. Prog Lipid Res 2011;50(2):133-140.
  12. Farnaghi S, Crawford R, Xiao Y, Prasadam I. Cholesterol metabolism in pathogenesis of osteoarthritis disease. Int J Rheum Dis 2017;20(2):131-40.
  13. Yudoh K, Karasawa R. Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA). Aging (Albany NY) 2010;2(12):990-8.
  14. Gustafson B. Adipose tissue, inflammation and atherosclerosis. J Atheroscler Thromb 2010;17(4):332-41.
  15. Hoeven TA, Kavousi M, Ikram MA, van Meurs JB, Bindels PJ, Hofman A, et al. Markers of atherosclerosis in relation to presence and progression of knee osteoarthritis: a population-based cohort study. Rheumatology (Oxford) 2015 Sep;54(9):1692-8.
  16. Garcia-Gil M, Reyes C, Ramos R, Sanchez-Santos MT, Prieto-Alhambra D, Spector TD. et al. Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study. Sci Rep 2017 Jun 9;7(1):3147.
  17. Conaghan PG, Vanharanta H, Dieppe PA. Is progressive osteoarthritis an atheromatous vascular disease? Ann Rheum Dis 2005;64:1539-41.
  18. Bierma-Zeinstra SMA, Waarsing JH. The role of atherosclerosis in osteoarthritis. Best Pract Res Clin Rheumatol 2017;31(5):613-33.
  19. Bierma-Zeinstra SMA, Hoeven TA, Waarsing JH. Is having OA an independent risk factor for cardiovascular events? Osteoarthritis Cartilage 2017;25(7):997-9.
  20. Wen CY, Chen Y, Tang HL, Yan CH, Lu WW, Chiu KY. Bone loss at subchondral plate in knee osteoarthritis patients with hypertension and type 2 diabetes mellitus. Osteoarthritis Cartilage 2013;21(11):1716-23.
  21. Bierma-Zeinstra SM, Koes BW. Risk factors and prognostic factors of hip and knee osteoarthritis. Nat Clin Pract Rheumatol 2007;3(2):78-85.
  22. Courties A, Sellam J, Berenbaum F. Metabolic syndrome-associated osteoarthritis. Curr Opin Rheumatol 2017;29(2):214-22.
  23. Distel E, Cadoudal T, Durant S, Poignard A, Chevalier X, Benelli C. The infrapatellar fat pad in knee osteoarthritis: an important source of interleukin-6 and its soluble receptor. Arthritis Rheum 2009;60(11):3374-7.
  24. Baker JF, Walsh P, Mulhall KJ. Statins: a potential role in the management of osteoarthritis?. Joint Bone Spine 2011;78(1):31-4.
  25. Zhou M, Guo Y, Wang D, Shi D, Li W, Liu Y, et al. The cross-sectional and longitudinal effect of hyperlipidemia on knee osteoarthritis: Results from the Dongfeng-Tongji cohort in China. Sci Rep 2017 Aug 29;7(1):9739.
  26. Frey N, Hügle T, Jick SS, Meier CR, Spoendlin J. Hyperlipidaemia and incident osteoarthritis of the hand: a population-based case-control study. Osteoarthritis Cartilage 2017;25(7):1040-5.
  27. Xiong J, Long J, Chen X, Li Y, Song H. Dyslipidemia Might Be Associated with an Increased Risk of Osteoarthritis. Biomed Res Int 2020;2020:3105248.
  28. Gierman LM, Kühnast S, Koudijs A, Pieterman EJ, Kloppenburg M, van Osch GJ, et al. Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice--a translational model for atherosclerosis. Ann Rheum Dis 2014 May;73(5):921-7.
  29. Grässel S, Muschter D. Recent advances in the treatment of osteoarthritis. F1000Res. 2020;9:F1000 Faculty Rev-325.
  30. Verbruggen G, Wittoek R, Vander Cruyssen B, Elewaut D. Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification. Ann Rheum Dis 2012 Jun;71(6):891-8.
  31. Chevalier X, Ravaud P, Maheu E, Baron G, Rialland A, Vergnaud P, et al. Adalimumab in patients with hand osteoarthritis refractory to analgesics and NSAIDs: a randomised, multicentre, double-blind, placebo-controlled trial. Ann Rheum Dis 2015 Sep;74(9):1697-705.
  32. Aitken D, Laslett LL, Pan F, Haugen IK, Otahal P, Bellamy N. et al. A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis - the HUMOR trial. Osteoarthritis Cartilage 2018 Jul;26(7):880-7.
  33. Kloppenburg M, Ramonda R, Bobacz K, Kwok WY, Elewaut D, Huizinga TWJ, et al. Etanercept in patients with inflammatory hand osteoarthritis (EHOA): a multicentre, randomised, double-blind, placebo-controlled trial. Ann Rheum Dis 2018 Dec;77(12):1757-64.
  34. Lennernäs H. Clinical Pharmacokinetics of Atorvastatin. Clin Pharmacokinet 42 2003;1141-60.
  35. Abeles AM, Pillinger MH. Statins as antiinflammatory and immunomodulatoragents: a future in rheumatologic therapy? Arthritis Rheum 2006;54(2):393-407.
  36. Li GM, Zhao J, Li B, Zhang XF, Ma JX, Ma XL, et al. The anti-inflammatory effects of statins on patients with rheumatoid arthritis: A systemic review and meta-analysis of 15 randomized controlled trials. Autoimmun Rev 2018 Mar;17(3):215-25.
  37. Antonopoulos AS, Margaritis M, Lee R, Channon K, Antoniades C. Statins as anti-inflammatory agents in atherogenesis: molecular mechanisms and lessons from the recent clinical trials. Curr Pharm Des 2012;18(11):1519-30.
  38. Jain, M., Ridker, P. Anti-Inflammatory Effects of Statins: Clinical Evidence and Basic Mechanisms. Nat Rev Drug Discov 2005;4:977-87.
  39. Bernard MY Cheung, Karen SL Lam. Efficacy and safety of statin therapy in older. people: a meta-analysis of individual participant data from 28 randomised controlled trials. 2019 Feb 2;393(10170):407-15.
  40. Chow YY, Chin KY. The Role of Inflammation in the Pathogenesis of Osteoarthritis. Mediators Inflamm 2020;2020:8293921.
  41. Gasparyan AY, Ayvazyan L, Blackmore H, Kitas GD. Writing a narrative biomedical review: considerations for authors, peer reviewers, and editors. Rheumatol Int 2011 Nov;31(11):1409-17.
  42. Veronese N, Koyanagi A, Stubbs B, Cooper C, Guglielmi G, Rizzoli R, et al. Statin Use and Knee Osteoarthritis Outcomes: A Longitudinal Cohort Study. Arthritis Care Res (Hoboken) 2019 Aug;71(8):1052-8.
  43. Peeters G, Tett SE, Conaghan PG, Mishra GD, Dobson AJ. Is statin use associated with new joint-related symptoms, physical function, and quality of life? Results from two population-based cohorts of women. Arthritis Care Res (Hoboken) 2015;67(1):13-20.
  44. Riddle DL, Moxley G, Dumenci L. Associations between statin use and changes in pain, function and structural progression: a longitudinal study of persons with knee osteoarthritis. Ann Rheum Dis 2013;72(2):196-203.
  45. Heidari B, Hajian-Tilaki K, Babaei M. Determinants of pain in patients with symptomatic knee osteoarthritis. Caspian J Intern Med 2016;7(3):153-61.
  46. Heidari B, Javadian Y, Babaei M, Yousef-Ghahari B. Restorative effect of vitamin D deficiency on knee pain and quadriceps in knee osteoarthritis. Acta Med Iran 2015;53:466-70.
  47. Sanghi D, Mishra A, Sharma AC, Singh A, Natu SM, Agarwal S, et al. Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. Clin Orthop Relat Res 2013 Nov;471(11):3556-62.
  48. Cham S, Evans MA, Denenberg JO, Golomb BA. Statin-associated muscle-related adverse effects: a case series of 354 patients. Pharmacotherapy 2010;30(6):541-53.
  49. Chodick G, Amital H, Shalem Y, Kokia E, Heymann AD, Porath A, et al. Persistence with statins and onset of rheumatoid arthritis: a population-based cohort study. PLoS Med 2010 Sep 7;7(9):e1000336.
  50. Kadam UT, Blagojevic M, Belcher J. Statin use and clinical osteoarthritis in the general population: a longitudinal study. J Gen Intern Med 2013;28(7):943-9.
  51. Cheng YY, Kao CL, Lin SY, Chang ST, Wei TS, Chang SN, et al. Effect of an increased dosage of statins on spinal degenerative joint disease: a retrospective cohort study. BMJ Open 2018 Feb 8;8(2):e017442.
  52. Mansi IA, Mortensen EM, Pugh MJ, Wegner M, Frei CR. Incidence of musculoskeletal and neoplastic diseases in patients on statin therapy: results of a retrospective cohort analysis. Am J Med Sci 2013;345(5):343-8.
  53. Valdes AM, Zhang W, Muir K, Maciewicz RA, Doherty S, Doherty M. Use of statins is associated with a lower prevalence of generalised osteoarthritis. Ann Rheum Dis 2014 May;73(5):943-5.
  54. Burkard T, Hügle T, Layton JB, Glynn RJ, Bloechliger M, Frey N, et al. Risk of Incident Osteoarthritis of the Hand in Statin Initiators: A Sequential Cohort Study. Arthritis Care Res (Hoboken) 2018 Dec;70(12):1795-805.
  55. Wang J, Dong J, Yang J, Wang Y, Liu J. Association between statin use and incidence or progression of osteoarthritis: meta-analysis of observational studies Osteoarthritis Cart [published online ahead of print, 2020 Apr 29].
  56. Clockaerts S, Van Osch GJ, Bastiaansen-Jenniskens YM, Verhaar JA, Van Glabbeek F, Van Meurs JB, et al. Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study. Ann Rheum Dis 2012 May;71(5):642-7. Erratum in: Ann Rheum Dis 2012 Jul;71(7):1264.
  57. Haj-Mirzaian A, Mohajer B, Guermazi A, Conaghan PG, Lima JAC, Blaha MJ, et al. Statin Use and Knee Osteoarthritis Outcome Measures according to the Presence of Heberden Nodes: Results from the Osteoarthritis Initiative. Radiology 2019 Nov;293(2):396-404.
  58. Cook MJ, Sorial AK, Lunt M, Board TN, O'Neill TW. Effect of Timing and Duration of Statin Exposure on Risk of Hip or Knee Revision Arthroplasty: A Population-based Cohort Study. J Rheumatol 2020;47(3):441-8.
  59. Sarmanova A, Doherty M, Kuo C, Wei J, Abhishek A, Mallen C, et al. Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched longitudinal cohort study. Rheumatology (Oxford) 2020 Oct 1;59(10):2898-907. Erratum in: Rheumatology (Oxford) 2020 Oct 1;59(10):3120.
  60. Beattie MS, Lane NE, Hung YY, Nevitt MC. Association of statin use and development and progression of hip osteoarthritis in elderly women. J Rheumatol 2005;32(1):106-10.
  61. Eymard F, Parsons C, Edwards MH, Petit-Dop F, Reginster JY, Bruyère O, et al. Statin use and knee osteoarthritis progression: Results from a post-hoc analysis of the SEKOIA trial. Joint Bone Spine 2018 Oct;85(5):609-14.
  62. Michaëlsson K, Lohmander LS, Turkiewicz A, Wolk A, Nilsson P, Englund M. Association between statin use and consultation or surgery for osteoarthritis of the hip or knee: a pooled analysis of four cohort studies. Osteoarthritis Cartilage 2017;25(11):1804-13.
  63. Dell'Isola A, Allan R, Smith SL, Marreiros SS, Steultjens M. Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature. BMC Musculoskelet Disord 2016 Oct 12;17(1):425.