Loading...
 
Mediterr J Rheumatol 2020;31(Suppl 2):304-5
Potential Role of Anti-Complement Agents in the Treatment of COVID-19-Related ARDS
Authors Information
1. Department of Internal Medicine, General Hospital of Amaliada, Amaliada, Greece
2. Rheumatology Clinic, 401 General Military Hospital of Athens, Athens, Greece
3. Paediatric Clinic, General University Hospital of Alexandroupolis, Alexandroupolis, Greece


ChristinaSpanopoulou, Dimitrios Kassimos, Dimitrios Cassimos
References
  1. Rawal G, Yadav S, Kumar R. Acute Respiratory Distress Syndrome: An Update and Review. J Transl Int Med 2018;6(2):74-7.
  2. Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 2020;395(10229):1033-4.
  3. Bosmann M, Ward PA. Role of C3, C5 and anaphylatoxin receptors in acute lung injury and in sepsis. Adv Exp Med Biol 2012;946:147-59.
  4. Garcia CC, Weston-Davies W, Russo RC, Travares LP, Rachid MA, Alves-Filho JC, et al. Complement C5 activation during influenza A infection in mice contributes to neutrophil recruitment and lung injury. PLoS One 2013;8(5):e64443.
  5. Wang R, Xiao H, Guo R, Li Y, Shen B. The role of C5a in acute lung injury induced by highly pathogenic viral infections. Emerg Microbes Infect 2015;4(5):e28.
  6. Jiang Y, Zhao G, Song N, Li P, Chen Y, Guo Y, et al. Blockade of the C5a-C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV. Emerg Microbes Infect 2018;7(1):77.
  7. Sun S, Zhao G, Liu C, Fan W, Zhou X, Zeng L, et al. Treatment with anti-C5a antibody improves the outcome of H7N9 virus infection in African green monkeys. Clin Infect Dis 2015;60(4):586-95.
  8. https://clinicaltrials.gov/ct2/show/NCT04333420
  9. Skattum L, van Deuren M, van der Poll T, Truedsson L. Complement deficiency states and associated infections. Mol Immunol 2011;48:1643-55.
  10. Feldmann M, Maini RN, Woody JN, Holgate ST, Winter G, Rowland M, et al. Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed. Lancet 2020 2-8 May;395(10234):1407-9.
  11. Seguin A, Galicier L, Boutboul D, Lemiale V, Azoulay E. Pulmonary involvement in patients with hemophagocytic lymphohistiocytosis. Chest 2016;149:1294-301.